Circulating metabolites associated with objectively measured sleep duration and sleep variability in overweight/obese participants: A metabolomics approach within the SATIN study
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Circulating metabolites associated with objectively measured sleep duration and sleep variability in overweight/obese participants : A metabolomics approach within the SATIN study. / Papandreou, Christopher; Camacho-Barcia, Lucia; García-Gavilán, Jesús; Hansen, Thea Toft; Hjorth, Mads Fiil; Halford, Jason C G; Salas-Salvadó, Jordi; Sjödin, Anders Mikael; Bulló, Mónica.
I: Sleep, Bind 42, Nr. 5, zsz030, 2019.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Circulating metabolites associated with objectively measured sleep duration and sleep variability in overweight/obese participants
T2 - A metabolomics approach within the SATIN study
AU - Papandreou, Christopher
AU - Camacho-Barcia, Lucia
AU - García-Gavilán, Jesús
AU - Hansen, Thea Toft
AU - Hjorth, Mads Fiil
AU - Halford, Jason C G
AU - Salas-Salvadó, Jordi
AU - Sjödin, Anders Mikael
AU - Bulló, Mónica
N1 - CURIS 2019 NEXS 086
PY - 2019
Y1 - 2019
N2 - Objectives: To investigate the associations of circulating metabolites with sleep duration and sleep variability. We also assessed the ability of metabolites to discriminate between sleep duration and sleep variability categories.Methods: Cross-sectional analysis of 205 participants with overweight/obesity from the "Satiety Innovation" (SATIN) study. A targeted metabolite profiling (n = 159 metabolites) approach was applied using three different platforms (NMR, LC-MS, GC-MS). Associations between circulating metabolite concentrations and accelerometer-derived sleep duration and variability in sleep duration were assessed using elastic-net regression analysis. Ten-fold cross-validation was used to estimate the discriminative accuracy of metabolites for sleep duration, and sleep variability categories.Results: A metabolite profile, including acyl-carnitines (C11:0/C5:1-DC/iso-C11:0, 2-M-C4:1/3-M-C4:1, C4:0); sphingomyelins (42:1, 33:1); glycerol; stearic acid; 2- and 3- hydroxyl-butyric acid; docosahexaenoic acid; serotonin; and phosphatidylcholine (34:2), was significantly associated with high sleep duration (4th plus 5th quintile). Ten metabolites, including acyl-carnitines (C18:1, C7:0, C6-OH); phosphatidylcholine (40:6, 37:4, 42:5); lyso-phosphatidylcholine, (20:1); sucrose; glutamic acid, and triacylglycerol (52:4), were significantly associated with high sleep variability (4th plus 5th quintile). The area under the curve was 0.69 (95% CI 0.62-0.75), and 0.63 (95% CI 0.53-0.72), in the multi-metabolite score for high sleep duration, and sleep variability, respectively. The variance in sleep duration explained by metabolites was 7%. No metabolites were selected for prediction of sleep variability (continuous).Conclusion: A small set of metabolites within distinct biochemical pathways were associated with high sleep duration and sleep variability. These metabolites appeared to moderately discriminate sleep duration and sleep variability categories.
AB - Objectives: To investigate the associations of circulating metabolites with sleep duration and sleep variability. We also assessed the ability of metabolites to discriminate between sleep duration and sleep variability categories.Methods: Cross-sectional analysis of 205 participants with overweight/obesity from the "Satiety Innovation" (SATIN) study. A targeted metabolite profiling (n = 159 metabolites) approach was applied using three different platforms (NMR, LC-MS, GC-MS). Associations between circulating metabolite concentrations and accelerometer-derived sleep duration and variability in sleep duration were assessed using elastic-net regression analysis. Ten-fold cross-validation was used to estimate the discriminative accuracy of metabolites for sleep duration, and sleep variability categories.Results: A metabolite profile, including acyl-carnitines (C11:0/C5:1-DC/iso-C11:0, 2-M-C4:1/3-M-C4:1, C4:0); sphingomyelins (42:1, 33:1); glycerol; stearic acid; 2- and 3- hydroxyl-butyric acid; docosahexaenoic acid; serotonin; and phosphatidylcholine (34:2), was significantly associated with high sleep duration (4th plus 5th quintile). Ten metabolites, including acyl-carnitines (C18:1, C7:0, C6-OH); phosphatidylcholine (40:6, 37:4, 42:5); lyso-phosphatidylcholine, (20:1); sucrose; glutamic acid, and triacylglycerol (52:4), were significantly associated with high sleep variability (4th plus 5th quintile). The area under the curve was 0.69 (95% CI 0.62-0.75), and 0.63 (95% CI 0.53-0.72), in the multi-metabolite score for high sleep duration, and sleep variability, respectively. The variance in sleep duration explained by metabolites was 7%. No metabolites were selected for prediction of sleep variability (continuous).Conclusion: A small set of metabolites within distinct biochemical pathways were associated with high sleep duration and sleep variability. These metabolites appeared to moderately discriminate sleep duration and sleep variability categories.
KW - Faculty of Science
KW - Metabolomics
KW - Sleep duration
KW - Sleep variability
KW - SATIN
U2 - 10.1093/sleep/zsz030
DO - 10.1093/sleep/zsz030
M3 - Journal article
C2 - 30722060
VL - 42
JO - Sleep (Online)
JF - Sleep (Online)
SN - 0161-8105
IS - 5
M1 - zsz030
ER -
ID: 213152890