Tramadol does not improve performance or impair motor function in trained cyclists
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Tramadol does not improve performance or impair motor function in trained cyclists. / Bejder, Jacob; Andersen, Andreas Breenfeldt; Bonne, Thomas Christian; Piil, Jacob Feder; Hagen, Linn Camilla Hauan; Dehnes, Yvette; Eibye, Kasper Hvid; Nybo, Lars; Nordsborg, Nikolai Baastrup.
I: Medicine and Science in Sports and Exercise, Bind 52, Nr. 5, 2020, s. 1169-1175.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Tramadol does not improve performance or impair motor function in trained cyclists
AU - Bejder, Jacob
AU - Andersen, Andreas Breenfeldt
AU - Bonne, Thomas Christian
AU - Piil, Jacob Feder
AU - Hagen, Linn Camilla Hauan
AU - Dehnes, Yvette
AU - Eibye, Kasper Hvid
AU - Nybo, Lars
AU - Nordsborg, Nikolai Baastrup
N1 - CURIS 2020 NEXS 118
PY - 2020
Y1 - 2020
N2 - Purpose: To investigate the hypothesis that a therapeutic oral dose of Tramadol improves cycling time trial performance and compromises motor-cognitive performance in highly trained cyclists.Methods: Following two familiarization trials, 16 highly trained cyclists completed a preloaded time trial (1 hour at 60 % of peak power followed by a 15 km time trial) after ingestion of 100 mg Tramadol or placebo in a double-blind placebo-controlled counterbalanced cross-over design separated by at least 4 days wash-out. Visuo-motor tracking and math tasks were completed during the preload (n=10) to evaluate effects on cognition and fine motor performance.Results: Time trial mean power output (298±42 W vs. 294±44 W) and performance (1474±77 s vs. 1483±85 s) were similar with Tramadol and placebo treatment, respectively. In addition, there were no differences in perceived exertion, reported pain, blood pH, lactate or HCO3 concentrations across trials. Heart rate was higher (P<0.001) during the Tramadol time trial (171±8 bpm) compared to placebo (167±9 bpm). None of the combined motor-cognitive tasks were impaired by Tramadol ingestion, in fact fine motor performance was slightly improved (P<0.05) in the Tramadol trial compared to placebo.Conclusion: In highly trained cyclists, ingestion of 100 mg Tramadol does not improve performance in a 15 km cycling time trial that was completed after a one hour preload at 60 % peak power. Additionally, a therapeutic dose of Tramadol does not compromise complex motor-cognitive or simple fine motor performances.
AB - Purpose: To investigate the hypothesis that a therapeutic oral dose of Tramadol improves cycling time trial performance and compromises motor-cognitive performance in highly trained cyclists.Methods: Following two familiarization trials, 16 highly trained cyclists completed a preloaded time trial (1 hour at 60 % of peak power followed by a 15 km time trial) after ingestion of 100 mg Tramadol or placebo in a double-blind placebo-controlled counterbalanced cross-over design separated by at least 4 days wash-out. Visuo-motor tracking and math tasks were completed during the preload (n=10) to evaluate effects on cognition and fine motor performance.Results: Time trial mean power output (298±42 W vs. 294±44 W) and performance (1474±77 s vs. 1483±85 s) were similar with Tramadol and placebo treatment, respectively. In addition, there were no differences in perceived exertion, reported pain, blood pH, lactate or HCO3 concentrations across trials. Heart rate was higher (P<0.001) during the Tramadol time trial (171±8 bpm) compared to placebo (167±9 bpm). None of the combined motor-cognitive tasks were impaired by Tramadol ingestion, in fact fine motor performance was slightly improved (P<0.05) in the Tramadol trial compared to placebo.Conclusion: In highly trained cyclists, ingestion of 100 mg Tramadol does not improve performance in a 15 km cycling time trial that was completed after a one hour preload at 60 % peak power. Additionally, a therapeutic dose of Tramadol does not compromise complex motor-cognitive or simple fine motor performances.
KW - Faculty of Science
KW - Pain
KW - Opioid
KW - Endurance
KW - Cognitive
KW - Athletes
KW - Exercise
U2 - 10.1249/MSS.0000000000002217
DO - 10.1249/MSS.0000000000002217
M3 - Journal article
C2 - 31809408
VL - 52
SP - 1169
EP - 1175
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
SN - 0195-9131
IS - 5
ER -
ID: 231553587